Improved Toxicology Methods will help reduce late stage drug failure.

February 7 2004--Research and Markets announces the addition of Predictive Toxicology to its offerings.

Given the high cost of late-stage failure in drug development and the high financial and social cost of adverse drug reactions, it is critical to identify and eliminate toxic compounds as early as possible in the drug development process. Current toxicology methods have limited predictive power, contributing to an average $802 million drug development price tag per drug and more than 100,000 annual U.S. deaths due to adverse drug reactions. As technologies that extend the ability of scientists to predict toxic profiles of candidate compounds continue to emerge, drug development companies are presented with new, effective methods that promise to reduce both the development costs of failed trials through the early attrition of poor drug candidates and the costs associated with adverse drug reactions.

This report analyzes emerging technologies and strategies to guide the discovery and development of safer, more effective drug therapies. Predictive Toxicology evaluates new approaches for predicting toxicity, particularly molecular biology methods, identifies the major opportunities and challenges to realizing predictive toxicology technologies, and provides a strategic and business outlook for companies adapting these approaches. The platforms used for evaluating toxicity—gene expression profiling methods, proteomics methods, bioinformatics—and the companies developing these technologies are examined in detail.

The discussion also encompasses the major strategies of discovering and applying surrogate biomarkers for predictive toxicology early in the discovery process.    

For a complete index of this report click on http://www.researchandmarkets.com/reports/44932

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